Puspitarini, P M A and Pratama, I S and Suryadi, B F (2019) ANTI-DIARRHEAL ACTIVITY OF AQUEOUS EXTRACT OF NAGASARI FLOWERS (Mesua ferrea L.) IN BALB/c MICE INDUCED BY Escherichia coli. JURNAL FARMASI SAINS DAN KOMUNITAS, 16 (2). pp. 50-55. ISSN 1693-5683; 2527-7146
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Abstract
Nagasari (Mesua ferrea L.) is empirically used for management for diarrhea in Nusa Tenggara Barat Province. However, the safety and efficacy of the nagasari have not been scientifically validated in an animal model. This study evaluated the activity of aqueous extract of the nagasari flowers in BALB/c mice induced by Escherichia coli to determine the effective dosage for anti-diarrheal effect. The aqueous extract of nagasari flowers (0,4% (w/v); 0,8% (w/v); and 1,6% (w/v)) was administered orally to 3 groups of mice, whereas negative and positive control received aquadestilate and ciprofloxacin 130 mg/kgBW respectively orally once daily for 3 days. The frequency and consistency of feces were observed then the total colony of E. coli in feces was calculated using colony counter. Aqueous extract of nagasari flowers at concentration 1,6% showed significant inhibitory activity against Escherichia coli comparable with positive controls (diarrhea index 0,425; p>0,05 and total colony of E. coli in feces 100,2; p>0,05). This study provides scientific support for the traditional use of aqueous extract of nagasari flowers for the treatment of diarrheal diseases.
| Item Type: | Article |
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| Keywords (Kata Kunci): | anti-diarrheal; Aqueous extract; diarrhea index; Escherichia coli; nagasari |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | Dr. Bambang Fajar Suryadi |
| Date Deposited: | 17 Dec 2021 01:34 |
| Last Modified: | 17 Dec 2021 01:34 |
| URI: | http://eprints.unram.ac.id/id/eprint/26553 |
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