Kadriyan, Hamsu and Yudhanto, Didit and Djannah, Fathul and Aryani, I Gusti Ayu T and Sulaksana, Muhammad Alfian Korespondensi - Correlation of Cancer Stage with Expression of LMP-1 and BCL-2 in Patients with Undifferentiated Nasopharyngeal Cancer. Akademi Sains Malaysia.
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Abstract
Staging is one of the considerations in treatment and prognosis of nasopharyngeal cancer (NPC). Previous studies have found an increased expression of latent membrane protein-1, LMP-1, which is an oncoprotein of Epstein-Barr Virus in NPC. BCL-2 is an anti-apoptosis protein which may be related to the stage of NPC. However, the correlation between NPC stage and the expression of LMP-1 and BCL-2 remains unclear. The aim of this study was to investigate the correlation between the stage of undifferentiated NPC and the expression of protein LMP-1 and BCL-2 in forty-four patients, aged between 20–79 years old, who received treatment in West Nusa Tenggara General Hospital, Indonesia. Most of the cases were found in the advanced stage (stages III and IV). The presence of BCL-2 and LMP�1 proteins was detected by immunohistochemical (IHC) staining. Approximately 34% of the biopsies showed positive LMP-1 expression in tumour cells and 66% were positive for BCL-2 expression. While staging was moderately correlated with LMP-1 expression (r = 0.421, p = 0.004), it was strongly correlated with BCL-2 expression (r = 0.610, p = 0.001). In conclusion, staging is very important in the treatment of NPC, it may be affected by the expression of LMP-1 and BCL-2.
| Item Type: | Other |
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| Keywords (Kata Kunci): | NPC; staging; LMP-1; BCL-2; IHC |
| Subjects: | A General Works > AI Indexes (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | Hamsu Kadriyan |
| Date Deposited: | 25 Nov 2022 01:55 |
| Last Modified: | 25 Nov 2022 01:55 |
| URI: | http://eprints.unram.ac.id/id/eprint/33393 |
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