Kadriyan, Hamsu and Djannah, Fathul and Habib, Philip and Cahyawati, Triana Diah and Siddik, Nurhidayati
(2022)
Jurnal - Well-organized Granuloma Lymphadenitis Tuberculosis Expressed Lower Macrophage Migration Inhibitory Factor (MIF) Score Compared to the Poorly-organized Granuloma.
Indonesian Biomedical Journal.
pp. 1-7.
ISSN 2085-3297
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In Press - The Expression of MIF in the Lymphadenitis Tuberculosis (Kadriyan H, et al.).pdf
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Abstract
BACKGROUND: The case of extra-pulmonary
tuberculosis (EPTB) is common and the most
type of extra-pulmonary tuberculosis found
is lymphadenitis TB (LnTB). Macrophage migration
inhibition factor (MIF) is correlated with TB, and low
level of MIF was correlated to Mycobacterium bacteremia.
Deficiency of MIF macrophage is known to be correlated
to the increased of a lung pathology; however, its role on
pathogenesis LnTB remains unclear. Hence, this study was
conducted to analyze the correlation of MIF in several type
of granuloma organization in LnTB.
METHODS: Block paraffin of the lymphoid tissue
infected with M. bacteremia were analyzed with
immunohistochemistry (IHC) to assess the MIF expression,
by counting the immunoreactivity score (IRS) according
to the intensity of stained cells and the level of staining.
The histopathology type of LnTB was divided into well-organized granuloma (WOG) and poorly-organized
granuloma (POG) based on the granuloma characteristics.
RESULT: Among 100 tissues samples that fulfilled the
study criteria, WOG was found in 51% cases. MIF was
expressed mild positive in 21% samples, on the other hand,
79% was not expressed. There was a significant difference
of MIF negative, as was found in 98% of WOG group while
only 59% was found in POG group (p<0.001).
CONCLUTION: There is a significant correlation between
MIF expression with the type of granuloma organization
in LnTB. The expression of MIF in WOG group is mostly
negative, as well as a half of the POG group. This results
may suggests that MIF plays a role in the pathogenesis of
granuloma formation in LnTB.
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