Laksmana, Ngakan Putu Proudy and Lestari, Rizka Vidya and Sahidu, M Ghalvan and Hunaifi, Ilsa and Padauleng, Novrita and NURHIDAYATI, NURHIDAYATI Peer Review Artikel 6: Pengaruh kadar gula darah puasa terhadap ekspresi Glucose transporter type-4 (GLUT4) neuron hipokampus pada tikus model diabetes. Universitas Mataram.
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Abstract
Background: Diabetes mellitus causes many complications, both microvascular and macrovascular, especially cognitive function. Related studies are being carried out to determine the relationship between diabetes and cognitive decline as assessed through GLUT4 expression in the hippocampus. The aimed of this study was to determine the effect of fasting blood sugar on hippocampal neuronal GLUT4 expression in STZ and NA-induced diabetic rats. Methods: This study was an experimental design, using 24 males Rattus novergicus which were divided into a control group terminated on day 14 (A0) and 28 (B0) and a diabetes group terminated on day 14 (A1) and 28 (B2). Diabetes was induced using intraperitoneal injection of streptozotocin (STZ) and Nicotinamide (NA). Spatial memory (travel time) of rats was assessed on days 14 and 28. Sampling used secondary data, fasting blood glucose (FBG) was measured using a glucometer and brain tissue was taken to assess GLUT4 expression using immunohistochemical methods. Differences in the mean FBG and GLUT4 expression between groups on days 14 and 28 and were tested statistically using SPSS version 22 Results: The mean FBG and GLUT4 expression in the diabetic group were significantly higher than those in the control group on day 14 and day 28. However, it was not significant compared between diabetes groups on day 14 and day 28. Immunohistochemical examination confirmed these results. There is a strong correlation between mean FBG levels and mean GLUT4 expression with travel time in the diabetes group on days 14 and 28 (r=0.88, p<0.05). Conclusion: Fasting blood glucose levels significantly affected hippocampal neuronal GLUT4 expression in STZ and NA-induced diabetic rats.
| Item Type: | Other |
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| Keywords (Kata Kunci): | Diabetes mellitus, fasting blood glucose, GLUT4 expression, animal models |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | dr. Ilsa Hunaifi Sp.S |
| Date Deposited: | 28 Apr 2023 00:18 |
| Last Modified: | 28 Apr 2023 00:18 |
| URI: | http://eprints.unram.ac.id/id/eprint/37107 |
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