Ekawanti, Ardiana (2018) C16 KARYA : Development of Animal Model for The Study of Gout and Dyslipidemia by Diet Modification. Proceeding of 1st ICWBB.
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Abstract
Degenerative diseases is tend to be rise nowadays. Hyperuricemia and dyslipidemia are condition that play an important role in pathogenesis of several degenerative diseases e.g. cardiovascular diseases such as hypertension, infarct myocard, etc. Since ethical barrier is critical issue in studying the mechanism of these disease in real patien,t so that, animal laboratory model is required. This research objective was to find out the nutrition formula, route and duration of diet in order to develop animal model for hyperuricemia and hypercholesterol condition. Research method was experimental laboratory research which was used post test only control group design. Male Rattus norvegicus wistar strain were divided into four groups: group (A) group fed by standard animal diet, group (B) group was given high cholesterol and high purin diet in duration of 14 days, group (C) group was given high cholesterol and high purin diet in duration of 21 days group (D) group was given high cholesterol and high purin diet in duration of 30 daysor given propyl thiouracil for the hypercholesterol group. The result were; cholesterol level of group A was 183±21.5 mg/dL, group B was 176.5±39.32 mg/dL, group C was 183.7±25.9, and group D was 242.17±40.2 mg/dL. Uric acid serum level for group A was 2.1±0.1 mg/dL, group B was 3.95±0.8 mg/dL, group C 3.35±0.3 mg/dL and group D was 8.3±3.4 mg/dL. Hypothesis was examined by using Kruskal Wallis test showed that there was a differencies among groups significantly with p value 0.000. It was concluded that induction of hypercholesterol and hyperuricemia condition by high cholesterol and high purin diet modification was effective after 21 days of fed by oral route
| Item Type: | Other |
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| Keywords (Kata Kunci): | hypercholesterol, hyperuricemia, induction, diet, animal model. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | dr. Ardiana Ekawanti, M.Kes |
| Date Deposited: | 02 May 2023 03:31 |
| Last Modified: | 02 May 2023 03:31 |
| URI: | http://eprints.unram.ac.id/id/eprint/37229 |
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