Taufik, Ahmad (2021) C3 JURNAL : Cell Multiplication in Platelet Rich Fibrin (PRF) and Platelet Rich Plasma (PRP) as Biofuels for Cartilage Tissue Engineering. Advances in Health Sciences Research.
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Lamp. C3 Cell Multiplication in Platelet Rich Fibrin (PRF) and Platelet Rich Plasma (PRP) as Biofuels for Cartilage Tissue Engineering (Jurnal Internasional Bereputasi) (Ketua).pdf Download (545kB) | Preview |
Abstract
Cartilage injury remains a major orthopedic challenge due to its low repair capacity, with the tendency to cause osteoarthritis. In addition, the treatment method involving platelet rich plasma (PRP) and platelet rich fibrin (PRF) as cartilage engineering components greatly anticipates promising recovery results. This research is aimed at determining the number of cells in platelet rich plasma (PRP) and platelet rich fibrin (PRF), particularly inflammatory cells. Blood specimens were collected from 30 rabbits that were divided into three treatment groups. The samples were then processed into control, PRP and PRF. This was followed by determining the number of cells in the form of platelets, leukocytes, lymphocytes, neutrophils and monocytes. According to the blood test results, the number of platelets increased by 3.8 and 4.5-fold in the PRP and PRF groups, respectively. Furthermore, 2 times (2.1-fold) increment was observed in leukocyte concentration for PRF, but zero in PRP. Conversely, the number of lymphocytes, neutrophils and monocytes decreased to 82, 72 and 40%, correspondingly, while PRP still showed no change. Based on the overall results and discussion, the number of platelets in both PRP and PRF increased severally, while leukocyte only occurred in PRF. This multi-fold expansion accompanied by growth factors has the capacity to accelerate cartilage recovery. Furthermore, the presence of inflammatory cells enhances the healing potential already existing in PRF.
| Item Type: | Article |
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| Keywords (Kata Kunci): | Cartilage engineering, Platelet rich fibrin, platelet rich plasma, Growth factor |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | dr. Ahmad Taufik S, Sp.OT |
| Date Deposited: | 05 May 2023 03:02 |
| Last Modified: | 05 May 2023 03:02 |
| URI: | http://eprints.unram.ac.id/id/eprint/37341 |
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