Jurnal - Clinical and laboratory comparison between End-Stage Kidney Disease patients with and without COVID-19: a cross-sectional study in a top referred hospital of West Nusa Tenggara

Asmara, I Gede Yasa and Agustriadi, I Gusti Ngurah Ommy and Sujaya, I Made and Thalib, Salim Said and Lestari, Rina and Fatrullah, Suryani Padua and Widiasari, Komang Sri Rahayu and Ajmala, Indana Eva and Octora, Metta (2022) Jurnal - Clinical and laboratory comparison between End-Stage Kidney Disease patients with and without COVID-19: a cross-sectional study in a top referred hospital of West Nusa Tenggara. Bali Medical Journal, 11 (3). pp. 1074-1079. ISSN P-ISSN.2089-1180, E-ISSN: 2302-2914

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Abstract

Background: The initial presentation of hospitalized End-Stage Kidney Disease (ESKD) patients with and without coronavirus disease 2019 (COVID-19) is similar and can overlap. We aimed to compare clinical dan laboratory characteristics of the COVID-19 positive and negative patients to help clinicians screen and differentiate hospitalized ESKD patients. Methods: We reviewed data from the medical record of ESKD patients hospitalized between May 1, 2020, and April 30, 2021. The study comprised all suspected COVID-19 patients. The COVID-19 positive was based on results from RT-PCR for SARSCoV-2. The bivariate analysis was used to compare the positive and negative groups. The association of all characteristics and diagnosis of COVID-19 were then evaluated by multivariable analysis. Results: There was twenty-nine percent of confirmed COVID-19 in 176 ESKD patients. The proportion of dyspnea, pulmonary edema, pleural effusion, and cardiomegaly were lower in the COVID-19 positive group. Diastolic blood pressure, pulse rate, white blood cell differential counts, and potassium were lower in the COVID-19 positive group. Using a multivariate analysis, eosinophil count <0.04 x103 µl (P<0.001, OR 3.50, 95%CI:0.123-0.665), monocyte count <0.69 x103 µl (P=0.004, OR 2.54, 95%CI:0.166-0.931), and neutrophil-to-lymphocyte ratio (NLR) <3.13 (P=0.044, OR 3.18, 95%CI:0.102-0.968) were associated with the presence of COVID-19. Conclusions: Leukocyte differential count and chest x-ray should be evaluated as an initial screening of COVID-19 in hospitalized ESKD. Low levels of monocyte and eosinophil count and mild elevation of NLR were associated with COVID-19 in ESKD patients.

Item Type:	Article
Keywords (Kata Kunci):	COVID-19, ESKD, eosinophil, monocyte, NLR
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran
Depositing User:	dr Rina Lestari Sp.P
Date Deposited:	30 May 2023 03:19
Last Modified:	30 May 2023 03:19
URI:	http://eprints.unram.ac.id/id/eprint/38977

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