Yuanita, Emmy and Ulfa, Maria and Rahmadhini, Rizky Annisa and Dharmayani, Ni Komang Tri and Riyaldi, Aris and SUDIRMAN, SUDIRMAN (2023) Synthesis and Antioxidant Activity of Calix[4]resorcinarene Derivatives Compounds. Proceedings of The 1st Nusa Tenggara International Conference on Chemistry (NITRIC 2022). pp. 75-82. ISSN 2590-3195
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Abstract
Synthesis of calix[4]resorcinarene derivatives and their activity as an antioxidant has been carried out. The calix[4]resorcinarene was synthesized through a condensation reaction of resorcinol, valeraldehyde, and benzaldehyde using HCl as a catalyst with ethanol as a solvent (73 ℃, 24 h). Two synthesized products, C-butilcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were successfully prepared with 44.70% and 43.5% yield, respectively. Their chemical structure was elucidated by Fourier Transform Infrared (FTIR) and Proton Nuclear Magnetic Resonance (1H-NMR) analysis. The antioxidant activity assay of these compounds was evaluated through an in vitro assay of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The DPPH assay showed that the half-maximal inhibitory concentration (IC50) values of C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were 6.28 ppm and 18.76 ppm, respectively. This finding demonstrates that both C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene have very strong antioxidant properties.
| Item Type: | Article |
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| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan ilmu Pengetahuan Alam |
| Depositing User: | Dr. EMMY YUANiTA, S.Si, M.Si |
| Date Deposited: | 09 Jun 2023 02:37 |
| Last Modified: | 09 Jun 2023 02:37 |
| URI: | http://eprints.unram.ac.id/id/eprint/39534 |
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