Taufik, Ahmad and Dirja, Bayu Tirta and Utomo, Dwikora Novembri and Usman, Muhammad Andry and Sakti, Muhammad and Saleh, Muhammad Ruksal and Hatta, Mochammad and Budu, Budu Double membrane platelet-rich fibrin (PRF) – Synovium succeeds in regenerating cartilage defect at the knee: An experimental study on rabbit. A Cell Press Journal, 9 (3).
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Double membrane platelet-rich fibrin (PRF) – Synovium succeeds in regenerating cartilage defect at the knee An experimental study on rabbit.pdf Download (3MB) | Preview |
Abstract
Background: This study aims to prove the healing results (regeneration) in cartilage defects using a combination treatment of microfractures and transplantation synovium-platelet rich fibrin (SPRF). Methods: A cartilage defect was made in the trochlear groove of the knee of adult New Zealand white rabbits, and was classified into three treatment groups. The group 1 was cartilage defect without treatment, 2 with microfracture treatment, and 3 with microfracture covered with a synovium-platelet rich fibrin (S-PRF) membrane. Twelve weeks after the intervention, the animals were macroscopically and histologically examined, and evaluated by the International Cartilage Repair Society (ICRS). Additionally, the expression of aggrecan and type 2 collagen was examined by real-time-PCR. Results: The ICSR scores for macroscopic were significantly higher in the microfracture and S-PRF transplant group than in the other groups. Also, the ICSR scores for histology were significantly higher in this group. The expression of aggrecan and type 2 collagen was higher in the group that received complete treatment. Conclusions: Microfractures and transplantation of synovium-platelet rich fibrin (S-PRF) can regenerate knee cartilage defects which have been shown to increase the expression of mRNA aggrecan and mRNA type 2 collagen resulting in excellent repair
| Item Type: | Article |
|---|---|
| Keywords (Kata Kunci): | Cartilage defect Microfracture Platelet-rich fibrin Synovium |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | dr. Ahmad Taufik S, Sp.OT |
| Date Deposited: | 21 Jun 2023 23:30 |
| Last Modified: | 21 Jun 2023 23:30 |
| URI: | http://eprints.unram.ac.id/id/eprint/40177 |
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