Sudarma, I Made and Ulfa, Maria and Sarkono, Sarkono (2009) CHEMICAL TRANSFORMATION OF EUGENOL ISOLATED FROM CLOVE OIL TO 4-ALLYL-2-METHOXY-6-SULFONICPHENOL AND 4-ALLYL-2-METHOXY-6-AMINOPHENOL. Indonesian Journal of Chemistry, 9 (2). pp. 267-270. ISSN 1411-9420/2460-1578
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Abstract
The overall objective of this research was to develop new compounds with potential biological activity from readily accessed natural products, in particular eugenol. Eugenol has been reported to posses antioxidant and anticancer properties. In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. The main aim of this preliminary research was to isolate eugenol from clove oil and made its sulfonic and amine derivatives through chemical transformation. Clove oil was extracted from clove buds with dichloromethane and followed by isolation of eugenol using column chromatography to afford eugenol (73%). Eugenol has been reported to posses antioxidant and anticancer properties. In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. Eugenol was transformed to its sulfonic derivative in moderate yield by treatment with chlorosulfonic acid and to its amine by reduction of its nitro derivative. This transformation was rapidly confirmed by GC-MS analysis which showed significance molecular ion at m/z 244 corresponding to molecular formula C10H12SO5. and at m/z 179 corresponding to molecular formula C10H11O2NH2.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan ilmu Pengetahuan Alam |
| Depositing User: | Dr Maria Ulfa |
| Date Deposited: | 21 Jul 2023 00:50 |
| Last Modified: | 21 Jul 2023 00:50 |
| URI: | http://eprints.unram.ac.id/id/eprint/41487 |
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