PENGARUH PEMBERIAN EKSTRAK ALKALOID SPONS LAUT (Clathria sp.) TERHADAP KADAR SGOT/SGPT MENCIT BALB/C YANG DIINFEKSI PLASMODIUM BERGHEI

Ardiansyah, Ardiansyah (2015) PENGARUH PEMBERIAN EKSTRAK ALKALOID SPONS LAUT (Clathria sp.) TERHADAP KADAR SGOT/SGPT MENCIT BALB/C YANG DIINFEKSI PLASMODIUM BERGHEI. S1 thesis, Universitas Mataram.

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Abstract

Background: The high prevalence of malaria caused by several factors, including the increasing of resistance to present antimalarial drugs. Resistance to chloroquine and sulphadoxine/pyrimethamine encourage researchers to find a new antiplasmodial agent, including from marine biotas. Clathria sp sponge is one of the marine biota that previously known containing alkaloid which has an antiplasmodial activity. Objective: The objective of this study was to evaluate the influence of marine sponge alkaloid extract administration (Clathria sp) to SGOT/SGPT level of Plasmodium berghei-infected Balb/C mice Methode: This research was an experimental study using Post Test Only Control Group Design. As much as 30 Balb/C mice were infected by P. berghei and randomized into 6 groups. 4 groups were given alkaloid extract at dose between 50-200 mg/kgBW and named as P1-P4 respectively and 2 control groups were treated with aquadest 5ml (K-) and chloroquine 5mg/kgBW (K+). All groups were treated using sondage for 7 days. In the last day, mice were terminated using ether and blood sample was obtained intracardialy. The data were analyzed using Oneway-Anova followed by LSD post hoc test. Result: There was significant difference (p <0.05) between treatment and control group. The significancy level was p=0,000 (p<0,05) in SGOT and p=0

Item Type: Thesis (S1)
Keywords (Kata Kunci): marine sponge, Clathria sp, SGOT, SGPT, malaria
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran
Depositing User: Ayus Suyarsih
Date Deposited: 24 Oct 2018 00:08
Last Modified: 24 Oct 2018 00:08
URI: http://eprints.unram.ac.id/id/eprint/9098

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