Rohadi, Muhammad Rosyid and Joni, Poniman and Muh, Husni Cengara (2020) Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma. Journal of Neurosciences in Rural Practice.
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Abstract
Background Meningioma is the most common brain tumor in which therapy and monitoring depend on the histopathological grade (World Health Organization [WHO] Grade). Progesterone receptor (PR) expression was reported positive in meningothelial cells and meningiomas with various degrees of positivity. We evaluated PR expression to determine its correlation with WHO Grade and each subtype of meningioma. Materials and Methods This study used 70 samples of paraffin block that were diag- nosed as meningioma and classified into WHO Grade I, II, and III. The paraffin blocks were sectioned in 5 μm thickness and immunohistochemically stained with the anti-PR antibody. Results PR expression was found positive in WHO Grade I and II groups, but negative in WHO Grade III group with the score of +2 found in clear cell and atypical subtype. These results were statistically significant with p-value < 0.05. Conclusion PR can be used as an additional marker to determine WHO Grade and subtype of meningioma.
| Item Type: | Article |
|---|---|
| Keywords (Kata Kunci): | progesterone receptor , meningioma , WHO Grade |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | Dr. dr. Rohadi SPBS |
| Date Deposited: | 19 Aug 2021 23:31 |
| Last Modified: | 19 Aug 2021 23:31 |
| URI: | http://eprints.unram.ac.id/id/eprint/23336 |
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