NGONGU DEPAMEDE, SULAIMAN and Wariata, Wayan and Sriasih, Made and Ali, Muhamad and Rosyidi, Anwar (2022) Preliminary study on designing the binder of sperm-1 synthetic vaccine using sequence-based methods and molecular docking. JOURNAL OF ADVANCED VETERINARY AND ANIMAL RESEARCH, 9 (1). pp. 122-127. ISSN 2311-7710
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Abstract
Objective: The main objective of this study is to design a synthetic vaccine from the binder of sperm-1 (BSP1). Materials and Methods: This study was carried out using bioinformatics-related techniques. BSP-1 has been chosen as one of the biomarkers of a ruminant’s male fertility. We hypothesize that the BSP1 synthetic vaccines, which contain T-cell epitopes, can produce antibodies more effectively for the development of a sperm fertility detection kit. A sequence of BSP-1 peptides A0A0K1YXR5 from Bubalus bubalis (Domestic water buffalo) origin has been decided to be used to develop the peptide vaccine. Results: In this study, we succeeded in making synthetic vaccines from BSP-1 with a peptide sequence of LPEDSVPDEERVFPFTYRNRKHF. The three-dimensional theoretical prediction analy�sis of the peptide binding pattern to its ligand, as well as the molecular docking, has also been revealed.
| Item Type: | Article |
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| Keywords (Kata Kunci): | A synthetic vaccine from the BSP-1 has been developed in this study with the amino acid sequence LPEDSVPDEERVFPFTYRNRKHF, which is buffer-soluble, and the three-dimensional theoretical prediction analysis of the peptide binding pattern of BSP-1 to its ligand, as well as molecular docking, has also been revealed |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology S Agriculture > SF Animal culture |
| Divisions: | Fakultas Peternakan |
| Depositing User: | Dr. drh. Anwar Rosyidi .MP |
| Date Deposited: | 19 May 2023 05:59 |
| Last Modified: | 19 May 2023 05:59 |
| URI: | http://eprints.unram.ac.id/id/eprint/38013 |
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