Yuanita, Emmy and SUDIRMAN, SUDIRMAN and Dharmayani, Ni Komang Tri and Ulfa, Maria and Syahri, Jufrizal Quantitative Structure-Activity Relationship (QSAR) and Molecular Docking of Xanthone Derivatives as Anti-Tuberculosis Agents. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 21. ISSN 2405-5794
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Abstract
Quantitative structure–activity relationship (QSAR) and molecular docking approach were carried out to design novel anti-tuberculosis agents based on xanthone derivatives. QSAR designed new compounds were calculated by Austin Model 1 (AM1) methods and analysis of multi-linear regression (MLR). The result showed that the best model as follows: Log IC50 = 3.113 + 11.627 qC1 + 15.955 qC4 + 11.702 qC9, this result has appropriate some statistical parameters (PRESS = 2.11, r2 = 0.730, SEE = 0. 3545, R = 0.6827, FCal/FTab = 4.68), and being used to design a potential anti-tuberculosis drugs with substituted amide, sulfoxide, and carboxylate group xanthone scaffold by a number of their inhibitory concentration (IC50). The mechanism action of sulfonamide substituted on the xanthone scaffold as anti-tuberculosis was carried out using molecular docking. Docking inhibition studies were carried out on MTB C171Q receptor (4C6X.pdb) as KasA inhibitors using by the discovery studio. Based on the binding interaction showed, the sulfonamide substituted xanthone has potential being the anti-tuberculosis drugs by KasA inhibitor for target drug activity.
| Item Type: | Article |
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| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan ilmu Pengetahuan Alam |
| Depositing User: | Dr. EMMY YUANiTA, S.Si, M.Si |
| Date Deposited: | 09 Jun 2023 02:37 |
| Last Modified: | 09 Jun 2023 02:37 |
| URI: | http://eprints.unram.ac.id/id/eprint/39536 |
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